Cisplatin macrophage

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August undefined, 2024

WebNov 1, 2014 · Cisplatin, a member of platinum agents, is one of the most widely used anticancer chemical drugs and a part of the treatment to many types of solid tumors, including head and neck, breast, testicular, ovarian, cervical, lung, and colorectal cancers (Rabik & Dolan, 2007 ). WebMar 10, 2024 · Original research: CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official.

Genes Free Full-Text Understanding HAT1: A Comprehensive …

WebCisplatin decreases mitochondrial function in sensory axons, and HDAC6 inhibition can promote axonal transport of healthy mitochondria. Indeed, the HDAC6 inhibitor normalized cisplatin-induced tibial nerve mitochondrial deficits. However, this was independent of macrophages and IL-10 signaling. WebM2 macrophage polarization modulates epithelial-mesenchymal transition in cisplatin-induced tubulointerstitial fibrosis Biomedicine (Taipei). 2016 Mar;6 (1):5. doi: 10.7603/s40681-016-0005-5. Epub 2016 Feb 10. Authors Chia-Cherng Yu 1 2 , Chiang-Ting Chien 3 , Tzu-Ching Chang 4 5 Affiliations hillary sleep calculator

Cisplatin Uptake in Macrophage Subtypes at the Single …

WebJan 31, 2024 · Here, we investigated the effects and mechanisms of cisplatin (DDP) on intracellular Mycobacterium smegmatis to tap the therapeutic potential of DDP in … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. Ubiquitin-specific protease (USP14) is involved in various pathological conditions ... WebNov 30, 2024 · For the first time, in vitro studies on cisplatin exposure addressed human monocytes and monocyte-derived macrophages (undifferentiated THP-1 monocytic … hillary simms of torbay

Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage …

Selective depletion of a CD64-expressing phagocyte subset ... - PNAS

WebOct 18, 2016 · Macrophages are the main component of inflammatory cells, and macrophages that infiltrate into the tumour microenvironment are referred to as tumour-associated macrophages (TAMs). ... Pirfenidone was recently reported to induce apoptosis of CAFs and to increase the anti-tumour effect of cisplatin in a murine model; however, … WebApr 13, 2024 · Background. Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the … smart cash cryptocurrency coin newsWebApr 14, 2024 · Other lines of research have revealed a relationship between HAT-1 and hepatocellular carcinoma (HCC) treatment with cisplatin, which is commonly associated with drug resistance in patients with this cancer . Notably, ... As a monocyte- and macrophage-specific scavenger receptor (CD163) that is shed into plasma, soluble … smart cash erste

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Cisplatin macrophage

Shenqi Fuzheng injection reverses M2 macrophage-mediated cisplatin …

WebFeb 7, 2024 · In the present study, we investigated the effects of magnolol on muscle wasting and macrophage subtypes in a cisplatin-induced sarcopenia mouse model. We showed that magnolol significantly attenuated the body weight and the muscle loss induced by cisplatin injection. WebNational Center for Biotechnology Information

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WebApr 11, 2024 · Sorafenib induces macrophage pyroptosis, ... The chemotherapy drug cisplatin (DDP) combined with low-dose BI2536, a polo-like Kinase 1(PLK1) inhibitor, can increase chemosensitivity by inducing ... WebNational Center for Biotechnology Information

WebMar 1, 2024 · Here, we demonstrated that cisplatin-stimulated classically activated macrophages (CAMs) promote ovarian cancer cell migration by increasing CCL20 production, which activates its receptor CCR6 on ovarian cancer cells, triggering … WebHere, we show that targeting tumour-associated macrophages by colony-stimulating factor-1 receptor (CSF-1R) blockade in the K14cre;Cdh1 F/F ;Trp53 F/F transgenic mouse model for breast cancer stimulates intratumoural type I interferon (IFN) signalling, which enhances the anticancer efficacy of platinum-based chemotherapeutics.

WebJun 11, 2024 · VNS treatment significantly suppressed cisplatin-induced kidney injury. This effect was abolished by splenectomy, while adoptive transfer of GTS-21-treated … WebMethods: We developed and compared different methods of loading exosomes released by mononuclear M1 and M2 macrophages from umbilical cord blood with cisplatin. We characterized the morphology, drug capacity, method of cellular entry, and antitumor efficacy of the exosomes in vitro.

WebApr 1, 2016 · Cisplatin is currently one of the most effective chemotherapeutic drugs used for treating ovarian cancer; however, resistance to cisplatin is common. In this study, we explored an experimental strategy for overcoming cisplatin resistance of human ovarian cancer from the new perspective of cancer cell metabolism.

WebApr 13, 2024 · Background: Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates that tumor-associated macrophages (TAMs) play an important role in chemoresistance of cancer. smart cash platinum plusWebOct 3, 2024 · Blocking Macrophage Migration Inhibitory Factor Protects Against Cisplatin-Induced Acute Kidney Injury in Mice. Macrophage migration inhibitory factor (MIF) is … smart cash crypto news price todayWebMar 20, 2024 · This study was designed to investigate whether the oral administration of M.C could decrease cisplatin-induced sarcopenia by modulating M2 macrophage polarization in mice. C57BL/6 mice were injected intraperitoneally with cisplatin (2.5 mg/kg) to mimic chemotherapy-induced sarcopenia. smart cash nzWebCisplatin does not affect the phenotype of CAMs, or the anti-tumor and chemo-sensitivity effects of CAMs on ovarian cancer cells. (A) mRNA expression of macrophage polarization markers as... smart cash register small businessWebMacrophage Stimulating Protein May Promote Tubular Regeneration after Acute Injury . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ... hillary simpsonWebAug 24, 2024 · 1. Introduction. Cisplatin (CDDP), a platinum-based anticancer agent, is one of the most commonly used chemotherapy drugs in the treatment of patients with various types of cancer, such as bladder, ovarian, head and neck, lung, testicular, cervical, esophageal, and breast cancer [].CDDP and its analogs, carboplatin and oxaliplatin, … smart cash financeWebJan 24, 2024 · When cisplatin was used in combination with SQFZ 40 μl/mL, the survival in the cisplatin 60 μM and 120 μM groups reduced by 50.8% and 72.5%, respectively, in the co-cultured MDA-MB-231/DDP cells and M2 macrophages . These results suggested that SQFZ improved the sensitivity of cisplatin through M2 macrophages. hillary slevin