Cisplatin pharmacokinetic
WebAug 22, 2024 · Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery (designated an orphan drug by FDA for this indication). Non-small Cell Lung Cancer WebDec 1, 1992 · The pharmacokinetic profile of vinorelbine is often described as a 3-compartment model characterised by a long terminal half-life that varies between 20 and 40 hours and a large apparent volume of distribution (Vd) of around 70 L/kg. 86 Pulmonary distribution of vinorelbine in patients with non-small-cell lung cancer D. Levêque, E. Quoix,
Cisplatin pharmacokinetic
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WebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … WebJul 22, 2024 · Pharmacokinetics not affected by mild (Cl cr 50–80 mL/minute), moderate (Cl cr 30 to <50 mL/minute), or severe (Cl cr <30 mL/minute) renal impairment. Pharmacokinetics have not been evaluated in patients with renal impairment requiring dialysis. Common Adverse Effects
WebMay 1, 2001 · Population Pharmacokinetic Analysis of Cisplatin and Its Metabolites in Cancer Patients: Possible Misinterpretation of Covariates for Pharmacokinetic Parameters Calculated from the Concentrations of Unchanged Cisplatin, Ultrafiltered Platinum and Total Platinum Kazuhiko Hanada, Kazuyuki Nishijima, Hiroyasu Ogata, Shinji Atagi, Masaaki … WebAug 20, 2024 · cisplatin AND (pharmacokinetics OR population pharmacokinetics OR NONMEM) Statistical analysis and evaluation of the candidate models The unbound cisplatin PK parameter estimates and standard errors (from the bootstrap validation, where available), were extracted from the studies reporting the population PK models of cisplatin.
WebJun 19, 2024 · Cisplatin concentrations were determined in plasma and ultrafiltrate samples collected on each of six cycles of a monotherapy regimen, beginning with a dose of 1.6 mg/kg at 16 days of age. Pharmacokinetic data were analyzed to generate clearance (CL) and area under the curve (AUC 0–∞) for each administration. WebApr 21, 2004 · The pharmacokinetics of unbound and total cisplatin was each ascribed a two-compartment model with linear elimination. The parameters of the basic pharmacokinetic model were CL, the systemic …
WebPharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in patients with normal and impaired renal function. In vitro studies with plasma and urine demonstrated that, in contrast to cisplatin, CBDCA is a stable complex [t 1/2 - 37 degrees; plasma, 30 hr, and urine, 20 to 460 hr]. small wedding venues in sussexWebMay 13, 2024 · Cisplatin is designated as highly emetogenic in the Guidelines for the Proper Use of Antiemetic Drugs, with nausea and vomiting occurring in more than 90% of patients. 18 Nausea and vomiting can be controlled with the appropriate use of antiemetics. small wedding venues in westchester nyWebJan 16, 2016 · Pharmacokinetic interactions were evaluated.Methods Plasma pazopanib and ultrafilterable cisplatin concentrations were obtained in 32 patients treated according to four levels of dose corresponding to 200, 400 or 600 mg daily dose of pazopanib and 60 or 75 mg/m2 of cisplatin. Two sequences of treatment… View on Springer ncbi.nlm.nih.gov small wedding venues in wvWebSep 21, 2016 · The pharmacokinetics and pharmacodynamics of docetaxel and cisplatin were compared in elderly and non-elderly patients. Results There were no differences in pharmacokinetics of docetaxel or cisplatin between elderly versus non-elderly patients with regard to clearance and volume of distribution. small wedding venues indianapolisWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … small wedding venues kitchenerWebMar 1, 1998 · The pharmacokinetics[PK] of cisplatin are complicated. It is demonstrated that the analysis of PK for free platinum is appropriate to predict the pharmacodynamic [PD] … hiking trails in yellowstoneWebJan 25, 2008 · For the cisplatin pharmacokinetic studies, the measured absorbance values for the 10 mice receiving cisplatin only were described with a one-compartment pharmacokinetic model. The measured absorbance values at 6 h for the two mice that received STS together with cisplatin were compared with the prediction for the model. … hiking trails inverness ca