WebKnut Larsson, Sven Ahlenius, in Techniques in the Behavioral and Neural Sciences, 1993. 8.2 Effects of 8-OH-DPAT and some related serotonergic agents. The administration of 8-OH-DPAT to male rats thus produced a marked facilitation of the ejaculatory behavior, to the point that many animals ejaculate on the first intromission. Normally, sensory feed-back … Web8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC 50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC 50, 5.42), 5-HT (pIC 50 5). 8-OH-DPAT has high affinity at 5-HT7 with a K i of 466 nM, and does not bind to 5-HT6 or 5-HT4. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
8-OH-DPAT - an overview ScienceDirect Topics
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