P53 dynamics control cell fate
WebDec 1, 2024 · Furthermore, Purvis et al. [7] and Chen et al. [8] indicated that p53 dynamics control cell fate between life and death in the DNA damage response. These mean that a deep understanding of the dynamics of p53 regulatory network in DNA damage response is extremely meaningful for developing cell control strategies. WebJul 28, 2009 · Finally, in the cell fate decision module, p53 controls the expression of the target genes; cell cycle arrest and apoptosis are separately evoked by the induction of p21 and p53AIP1. Thus, the damage signal is transmitted forward until DNA repair is completed or apoptosis is initiated.
P53 dynamics control cell fate
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Webp53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has … WebAbstract. Cells transmit information through molecular signals that often show complex dynamical patterns. The dynamic behavior of the tumor suppressor p53 varies depending …
Web(D) Left: Myc dynamics in cells born before hour 20 of imaging were grouped by cell fate (determined within 4 days after initial drug treatment). Mean ± SEM. Right: mean Myc-mNG levels in the first 3 h of drug treatment. Boxes denote 75 th, 50 th, and 25 th percentiles. Two-sided t test. From left to right, n = 25, 19, and 16 cells. Web(D) Left: Myc dynamics in cells born before hour 20 of imaging were grouped by cell fate (determined within 4 days after initial drug treatment). Mean ± SEM. Right: mean Myc …
WebNov 10, 2024 · p53 dynamics play a key role in cell fate decision. The p53 level exhibits distinct dynamic modes depending on the cell and stress types [ 13]. For example, uniform pulses can be evoked upon ionizing radiation, whereas only a dosage-dependent single pulse appears in response to ultraviolet (UV) radiation. WebInduction of p53 triggers multiple cellular programs ranging fromtransientresponses,suchasDNArepairand cell cycle arrest, to terminal fates such as …
Webto investigate how the dynamic response of MAPK and p53 may intersect in determining cell fate during the G2 checkpoint. We reveal the previously unnoticed pulsatile activation of MAPK signaling after DNA damage and show how it intersects with the cell-autonomous control of p53 dynamics. We find that
WebFeb 9, 2024 · p53 dynamics in the cell fate decision. Cells under the attack of different types of DNA damage can be directed to different fates. UV-induced DNA SSBs result in a single … key school indianapolisWebJan 7, 2016 · Signaling dynamics are known to encode and decode cellular information that controls cellular responses (Purivs and Lahav, 2013). p53 dynamics can control cell fate decision in response to DSBs, and cells that experience p53 pulses recover from DNA damage, whereas cells that are exposed to sustained p53 signaling frequently undergo … key school in fort worthWebMar 1, 2024 · PTMs can be specific to the type of DNA damage 120, 121, 122, 123, 124, 125, 126 and thus can accordingly direct the p53-mediated response and cell fate. Fig. 2: Regulation of p53 target... key school indianapolis indianaWebJan 23, 2024 · The dynamics model of tumor suppressor p53 system is employed to investigate how PTEN protein mediates p53 dynamics after DNA damage and it indicates that the moderate p53-dependent PTEN synthesis rate is required for p53 to oscillate, while the higher p53-dependent PTEN synthesis rate is needed for the p53 bi-stable switch. 1 … key school mascotWebOct 1, 2014 · When sustained induction of p53 activity was artificially stimulated by a temporally scheduled dose of the small molecule Nutlin-3, which inhibits Mdm2, cells chose the fate of senescence rather than apoptosis (Fig. 2C), suggesting that p53 oscillation functions as a cell fate determinant (Purvis et al., 2012). islander quartz watchWebJul 18, 2024 · In this review, we discuss the evolution of kinetic p53 modeling, multiple mechanisms for distinct p53 dynamics, and how the temporal p53 dynamics determine cell fate over the last 2 decades. islander realtyWebApr 11, 2024 · As the variable p53 levels resulted from the distinct p53 dynamics played a key role in promoting alternative cell fate outcomes of cell cycle arrest and cell death, as we elucidated before [ 15 ], it is important to understand the quantitative and mechanistic basis of the differential dynamic outputs of p53 pathway, which we elaborated below. key school neo