Pdgfrb creer
Splet032770 B6.129S- Pdgfra tm1.1(cre/ERT2)Blh /J Pdgfrα-CreER T2 mice have a cre/ERT2 fusion gene inserted into the start codon of the platelet derived growth factor receptor, … Splet21. apr. 2024 · Upon carotid artery ligation, PDGFRa-positive (+) cells were slowly recruited to the neointima and exhibited an immature SMC phenotype. In contrast, in a more severe wire denudation injury, PDGFRa+...
Pdgfrb creer
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SpletPDGFRβ-P2A-CreER T2 mice: a genetic tool to target pericytes in angiogenesis Angiogenesis. 2024 Nov;20 (4):655-662. doi: 10.1007/s10456-017-9570-9. Epub 2024 Jul … SpletWe have generated a novel mouse line expressing tamoxifen-inducible Cre-recombinase under the control of the platelet-derived growth factor receptor β promoter: PDGFRβ-P2A-CreER T2. We evaluated the expression of the PDGFRβ-P2A-CreER T2 line by crossing it with fluorescent reporter lines and analyzed reporter signal in the angiogenic retina ...
SpletUseful information about the protein provided by UniProt. Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers … Splet22. feb. 2024 · Between 16 and 18 weeks of WD feeding, mice were injected with tamoxifen to induce recombination of eYFP and Pdgfrb specifically in Myh11-CreER T2-expressing …
NG2+ vascular pericytes do not give rise to CAs. As PDGFRb lacks specificity to vascular mural cells, we generated another mouse line, NG2-CreER, by inserting CreER-P2A in frame with the translational start codon of the NG2 gene ( Figure 7 A) to examine the contribution of vascular pericytes to CAs. SpletIn the PDGFRb-P2A-CreER T2 -tdTomato mouse, an induction efficiency between 78.9 and 94.1% was achieved. TdTomato expression in the retina was restricted to PCs and vascular smooth muscle cells in the NG2-CreER™-tdTomato mouse, however, in the PDGFRb-P2A-CreER T2 -tdTomato mouse, tdTomato was also expressed in Müller glial cells. Conclusion
Splet27. apr. 2024 · The blood-brain barrier (BBB) is critical for protecting the brain and maintaining neuronal homeostasis. Although the BBB is a unique feature of the central nervous system (CNS) vasculature, not all brain regions have …
Splet10. nov. 2024 · Role of pericytes in the retina. Diabetic retinopathy is a major severe ocular complication associated with the metabolic disorder of diabetes mellitus. 1 The lack of a detailed knowledge about ... human geography for upscSpletThe Pdgfrb-Cre line has been used as a tool to specifically target pericytes and vascular smooth muscle cells. Recent studies showed additional targeting of cardiac and … holland employment servicesSplet07. mar. 2024 · The PDGFRα-CreER transgenic mouse was first developed to study oligodendrocyte precursor cells in the forebrain and spinal cord of adult mice. 27 The … holland en barrett creatineSplet030201 B6.Cg- Pdgfrb tm1.1(cre/ERT2)Csln /J PDGFRβ-P2A-CreER T2 mice express tamoxifen-inducible Cre recombinase under the direction of the murine platelet derived … holland entry requirements ukSplet03. jun. 2024 · For this, they created Pdgfra-DreER red fluorescent reporter mice and crossed them with Pdgfrb-CreER green fluorescent reporter mice. They used this tamoxifen-inducible system to screen adult organs for three populations of labeled cells: Pdgfra+ (red), Pdgfrb+ (green), and Pdgfra+Pdgfrb+ (yellow). holland en sherrySplet07. mar. 2024 · Mutation details : The mouse Pdgfb promoter was used to drive inducible expression of an improved cre gene fused to ERT2 and followed by an IRES-EGFP then an frt-flanked chloramphenicol resistance gene in vascular endothelium. The PAC used (RP21-629-J8) contains the entire Pdgfb gene with the cre cassette inserted immediately … human geography gcse aqaSplet21. mar. 2024 · In the PDGFRb-P2A-CreER T2-tdTomato mouse, an induction efficiency between 78.9 and 94.1% was achieved. TdTomato expression in the retina was restricted to PCs and vascular smooth muscle cells in the NG2-CreER™-tdTomato mouse, however, in the PDGFRb-P2A-CreER T2-tdTomato mouse, tdTomato was also expressed in Müller … human geography gcse