Tsc1 antibody

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August undefined, 2024

WebAug 24, 2012 · The endogenous interaction of TBC1D7 with the TSC1-TSC2 complex was confirmed in reciprocal immunoprecipitations with a panel of six unique antibodies to TSC1 or TSC2, along with an antibody raised against TBC1D7 (Figure 1 B), the specificity of which was confirmed through siRNA-mediated knockdown of TBC1D7 (Figure S1 E).TBC1D7 … WebThe regulation of the subcellular localization of phosphatase and tensin homologue (PTEN) is critical to its tumor-suppressing functions. Previously, we found that the activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR/S6 protein kinase (S6K) cascade triggers the nuclear export of PTEN duri …

Anti-TSC1 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

WebNov 10, 2024 · Tsc1 was immunoprecipitated from HEK293 cell lysates using anti-Tsc1 antibody and immunoblotted with indicated antibodies to confirm chaperone, co-chaperone, and client protein interaction. IgG was used as control. FLAG-tagged Hsp90α N-, M-, and C-domains were transiently expressed and immunoprecipitated from HEK293 cells. WebRabbit anti Human TSC1 antibody recognizes an epitope within the internal region of the 130kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1). Mutation within … open houses in langley bc

AMPK/TSC2/mTOR-signaling intermediates are not necessary for …

WebInvitrogen Anti-TSC1 Polyclonal, Catalog # PA5-20131. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) applications. This antibody reacts with Human, Mouse, Rat … Web5.2 TSC1–TSC2 complex. TSC1 and TSC2 genes were identified in 1997 and 1993 as the genetic loci mutated in the disease known as tuberous sclerosis complex (TSC) (European TSC Consortium, 1993; van Slegtenhorst et al., 1997). These genes’ products are two proteins, TSC1 and TSC2, which do not share any homology between them, and very little ... WebDetection of human and mouse TSC1 by western blot. Samples: Whole cell lysate (50 µg) from HeLa and mouse NIH3T3 cells prepared using NETN lysis buffer.Antibody: Affinity … open houses in lindenhurst ny

TSC1 Antibody (Phospho-Ser505) (OAAB01854) Aviva Systems …

Anti-TSC1 Antibodies Invitrogen - Thermo Fisher Scientific

WebImmunoprecipitation of TSC1 was performed on HAP1 cell lysates. Antibody-bead conjugates were prepared by adding 2 µg of TSC1 polyclonal antibody (Product # PA5 … Web"Phospho-Hamartin/TSC1 (Ser511) antibodies" comparison. At Proteintech, we pride ourselves on our antibody quality, customer service and transparency. As such, we are … open houses in land o lakes flWebRabbit TSC1 Rabbit pAb (A0720), validaed in WB,IHC,IF/ICC and tested in Human,, Mouse,, Rat. 100% Guaranteed. ABclonal provides free trial antibodies for target detection. Replacement to Abcam, Santa Cruz, Sigma and CST antibody. open houses in little neck ny

"WebMonoclonal Antibody for studying Hamartin/TSC1. Cited in 10 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, Hamartin/TSC1 (1B2) Mouse Monoclonal Antibody (CST #4963) is … " - Tsc1 antibody

Tsc1 antibody

hamartin Antibody (C-8) SCBT - Santa Cruz Biotechnology

WebThis is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown. Application Note. Anti-TSC1 Antibody has been tested for use in ELISA and Western ... WebThis antibody binds to Yeast LCB2. Format: Liquid or Lyophilized: Storage: Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use: Purity > 90% was determined by SDS-PAGE: Purification: Purified with Protein A or G affinity chromatography: Cellular Localization: Endoplasmic reticulum; Other locations

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WebMar 21, 2024 · In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, 28215400, 35772404).Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity … WebMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val640 of human TSC1. Background Tuberous …

WebFeb 3, 2024 · Double labeling with Tsc1 (Hamartin) and H +-ATPase antibodies demonstrated remarkable colocalization in cyst epithelial cells in Tsc1 KO mice (Fig. 3B). Double labeling with Tsc1 and AQP-2 antibodies indicated the expression of Tsc1 in the majority of cells lining the cysts with few and distinct AQP-2–expressing (principal cells … WebProduct Description. Mouse anti Human TSC1 antibody recognizes TSC1, also known as hamartin and tuberous sclerosis 1 protein. TSC1 encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in TSC1 have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript ...

WebDr. Constantinos Demetriades is a Molecular Cell Biologist and a European Research Council (ERC) Grantee. Currently, he holds a Max Planck Research Group Leader position (Associate Professor level) at the Max Planck Institute for Biology of Ageing (MPI-AGE) in Cologne. His work focuses on the intricate molecular and cellular mechanisms of nutrient sensing and … WebUrothelial carcinoma represents one of the most prevalent types of cancer worldwide, and its incidence is expected to grow. Although the treatment of the advanced disease was based on chemotherapy for decades, the developments of different therapies, such as immune checkpoint inhibitors, antibody drug conjugates and tyrosine kinase inhibitors, …

WebThis Anti-Harmartin (TSC1) Antibody is validated for use in WB, IH (P) for the detection of Harmartin (TSC1). Key Applications. Western Blotting. Immunohistochemistry (Paraffin) Application Notes. Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Harmartin in human skin tissue, melanocytes.

WebApr 14, 2024 · Phase III Abstracts presenting at AACR 2024. Drawing attention to the Phase II data readout, we have cancer vaccine players Moderna and Transgene excited about their personalized therapy.Merck is readily evaluating its flagship product as a combination in high-grade serous ovarian carcinoma, Aadi Biosciences heading towards grabbing a … open houses in lawrence ksWebImmunohistochemistry: TSC1 Antibody (3A2) [NBP2-46234] - Analysis of Human adult heart tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: TSC1 Antibody (3A2) [NBP2-46234] - Analysis of … iowa state vs iowa basketball 2021WebAntibodies that detect TSC1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, Dot blot and ELISA. These antibodies … iowa state vs clemson footballWebAntibodies. We have a collection of 534,170 monoclonal and polyclonal antibodies to most target proteins. They cover all major research species, applications, and are available in multiple conjugated forms. Our IHC-plus™ antibodies are highly characterized for use in FFPE human tissue Immunohistochemistry. open houses in lely country clubWebThis TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1. … open houses in long beach island nj tomorrowWeba 15 amino acid peptide from the middle region of human TSC1. TSC1 antibody will recognize both isoforms of TSC1. Packaging. 100 μg. Linkage. The action of this antibody can be blocked using blocking peptide SBP3505. Physical form. Solution in phosphate buffered saline containing 0.02% sodium azide. open houses in mansfield tx iowa state vs iowa basketball score